December 2019

A time-dependent role for the transcription factor CREB in neuronal allocation to an engram underlying a fear memory revealed using a novel in vivo optogenetic tool to modulate CREB function

  • by
http://feeds.nature.com/~r/npp/rss/current/~3/_0gu2K1hNCM/s41386-019-0588-0

Neuropsychopharmacology, Published online: 14 December 2019; doi:10.1038/s41386-019-0588-0

A time-dependent role for the transcription factor CREB in neuronal allocation to an engram underlying a fear memory revealed using a novel in vivo optogenetic tool to modulate CREB function


Discuss: ‘You have actually got dry macular degeneration, end of tale: a qualitative study into the experience of coping with non-neovascular age-related macular degeneration’

  • by
http://feeds.nature.com/~r/eye/rss/current/~3/aEvIGt2mdqc/s41433-019-0730-6

Eye, Published online: 13 December 2019; doi:10.1038/s41433-019-0730-6

Comment on: ‘You’ve got dry macular degeneration, end of story: a qualitative study into the experience of living with non-neovascular age-related macular degeneration’


[Comment] Choosing GLP-1 receptor agonists or SGLT-2 inhibitors by cardiorenal risk

  • by
https://www.thelancet.com/journals/landia/article/PIIS2213-8587(19)30414-0/fulltext?rss=yes

Type 2 diabetes is widely recognised as a cardiorenal-metabolic condition in which defective glucose homeostasis is associated with other metabolic disturbances and increased risk of cardiovascular and renal diseases, each of which can accentuate the others.1 Accordingly, a cardiorenal-metabolic perspective has been adopted in the current consensus report on the management of hyperglycaemia in type 2 diabetes.2 The report by the American Diabetes Association and the European Association for the Study of Diabetes emphasises an individualised approach that is underpinned by lifestyle measures and typically supported by initial glucose-lowering therapy with metformin.


Importance of breastfeeding in preventing diabetes reaffirmed in rat study

  • by
https://www.sciencedaily.com/releases/2019/12/191211215911.htm

New research published today shows that breastfeeding is crucial in preventing diabetes. The World Health Organization recommends breastfeeding as the sole source of nutrition for infants until six months of age, as this helps reduce child morbidity and mortality. In contrast, early weaning is associated with both the development of obesity and Type 2 diabetes in adulthood.


[Articles] A population-based analysis of suicidality and its correlates: findings from the National Mental Health Survey of India, 2015–16

  • by
https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(19)30404-3/fulltext?rss=yes

A national suicide prevention strategy that is comprehensive, using multisectoral approaches, is required to address the prevailing sociodemographic and other risk factors for reducing suicidality and suicide deaths in India. This study also has implications for other low-income and middle-income countries in south Asia, where sociodemographic factors play a crucial role for suicide prevention.