Heart Disease

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Genetic relevance and determinants of mitral leaflet size in hypertrophic cardiomyopathy


Whether mitral leaflet elongation is a primary phenotype of hypertrophic cardiomyopathy (HCM) is controversial. We investigated the genetic relevance and determinants of mitral leaflet size by performing exten…

Long Time Coming: ICD-11 Recognizes Stroke as Brain Disorder


After many years of stroke being subsumed within other parts of ICD, it now is listed under neurology. Once classified as a circulatory problem, stroke is a brain disorder … Read the rest

Omega-3 and Vit D of No Benefit for Kidney Function in Diabetes


Neither vitamin D3 nor omega-3 fatty acids affected eGFR at 5 years in a sub-study of the VITAL trial. Doctors need to make it clear to patients that there … Read the rest

Impact of a training program incorporating cardiac magnetic resonance imaging on the accuracy and reproducibility of two-dimensional echocardiographic measurements of left ventricular volumes and ejection fraction


Left ventricular (LV) ejection fraction (LVEF) assessed by two-dimensional echocardiography (2DE) is the most widely used parameter for clinical decision-making, but reproducibility and accuracy problems remai…

Prognostic Value of Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity


This systematic review and meta-analysis explores the prognostic and discriminatory value of echocardiographic left ventricular global longitudinal strain for the prediction of cancer therapy–related cardiac dysfunction.

Diabetes and baseline glucose are associated with inflammation, left ventricular function and short- and long-term outcome in acute coronary syndromes: role of the novel biomarker Cyr 61


Hyperglycemia in the setting of an acute coronary syndrome (ACS) impacts short term outcomes, but little is known about longer term effects. We therefore designed this study to firstly … Read the rest

Are Patients with Short-Duration Atrial Fibrillation at Risk for Stroke?


Patients with device-detected AF durations between 5 minutes and 24 hours and CHA2DS2-VASc scores of 3 and higher would probably benefit from anticoagulation.

Therapeutic Cooling of Patients with Arrest After Nonshockable Rhythms


Survivors who were cooled were more likely to have favorable neurological outcomes.

Benefit of early initiation of statins for FH


Nature Reviews Cardiology, Published online: 04 November 2019; doi:10.1038/s41569-019-0307-x

Statin therapy initiated during childhood in patients with familial hypercholesterolaemia (FH) slows the rate of carotid intima–media thickening and reduces … Read the rest

Global longitudinal strain as an Indicator of cardiac Iron overload in thalassemia patients


Cardiac involvement due to iron overload is the most common cause of morbidity and mortality in patients with thalassemia, and many patients remain asymptomatic until the late stages. Therefore, … Read the rest