[Comment] The sinister side of Cushing's therapy


Cushing’s syndrome remains one of the most intriguing disorders in endocrinology, for both its protean manifestations and problems in diagnosis, as well as the extraordinary changes seen in response to successful therapy.1 Such therapy, however, can be difficult to obtain, as surgery is not always successful and medical options can be unavailable or prohibitively expensive. Once exogenous sources of Cushing’s syndrome have been excluded, pituitary-dependent Cushing’s syndrome, or Cushing’s disease, represents the most frequent cause, with adrenal tumours, both benign and malignant, and the ectopic adrenocorticotropic hormone (ACTH) syndrome, as the major other causes.


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