Structure-function Relationship in Advanced Glaucoma After Reaching the RNFL Floor

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https://journals.lww.com/glaucomajournal/Fulltext/2019/11000/Structure_function_Relationship_in_Advanced.10.aspx

image Précis:
Although the circumpapillary retinal nerve fiber layer (cpRNFL) got to the dimension floor, the nasal macular area is necessary for analyzing main aesthetic feature in advanced glaucoma.
Objective:
To explore the relationship in between the main aesthetic area (VF) and also macular specifications acquired from spectral-domain optical comprehensibility tomography (SD-OCT) in clients with advanced glaucoma that got to the cpRNFL density dimension floor and also to identify whether the architectural adjustments gauged by SD-OCT serve for approximating the practical condition in these clients.
Techniques:
A total amount of 68 eyes from 68 clients with advanced glaucoma were consisted of. Just eyes having a typical cpRNFL density of ≤57 μm that got to the dimension floor were consisted of. Macular imaging making use of Cirrus SD-OCT and also 10 -2 Humphrey VF was executed. The VF suggest discrepancy was transformed to a straight range making use of unlogged 1/Lambert worths. The connections in between the main VF and also different macular specifications were established.
Outcomes:
Clients had a mean VF suggest discrepancy of −2069 dB and also a typical cpRNFL density of 51.76 ± 3.61 μm. Connections in between the VF and also all cpRNFL density specifications were not substantial. Nevertheless, substantial connections were located in between the main VF and also superonasal macular ganglion cell-inner plexiform layer density (r= 0.334; P= 0.003), internal nasal macular density (r= 0.301; P= 0.013), and also external nasal macular density (r= 0.331; P= 0.007).
Final thoughts:
Also after the cpRNFL had actually gotten to the dimension floor, a number of macular specifications revealed a statistically substantial relationship with practical condition in VF. Specifically, the evaluation of architectural adjustments in the nasal macular area might be essential in identifying the main VF in advanced glaucoma.

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